TGen Receives Approval for Patient Enrollment in Brain Cancer Clinical Trial

Glioblastoma (GBM) Pilot Trial funded by Ivy Foundation

In 2012, The Ben & Catherine Ivy Foundation awarded $10 million in grants for two groundbreaking brain cancer research projects at the Translational Genomics Research Institute (TGen). One of those projects has actually officially received the last regulatory approval from University of California, San Francisco, which means patient enrollment for the trial can easily begin.

In the $5-million-project, “Genomics Enabled Medicine in Glioblastoma Trial,” TGen and its clinical partners will certainly lead first-in-patient clinical trial studies that will certainly test promising brand-new drugs that may extend the survival of GBM patients. This multi-portion study will certainly take place in clinics across the country and TGen laboratories.

“GBM is one of the top three fastest-killing cancers out there and it affects individuals of all ages,” said Catherine (Bracken) Ivy, founder and president of The Ben & Catherine Ivy Foundation. “It is critical that we fund research that will certainly assistance patients live longer so we can easily study and treat brain cancer.”

The project begins along with a pilot study of 15 patients, using whole genome sequencing to study their tumor samples to assistance physicians find out just what drugs could be most beneficial.

To support molecularly informed clinical decisions, TGen labs additionally will certainly examine genomic data from at least 536 past cases of glioblastoma, as well as tumor samples from brand-new cases, producing tools that will certainly make a lot more recommendations in to exactly how glioblastoma tumors grow and survive. TGen additionally will certainly conduct a collection of pioneering lab examinations to measure cell-by-cell responses to various drugs.

“GBM is a disease that requires answers now, and we strongly believe those answers will certainly be found in the genome,” said Dr. David Craig, TGen’s Deputy Director of Bioinformatics, Director of TGen’s Neurogenomics Division, and one of the projects principal investigators. “Recognizing the genes that contribute to the survival of glioblastoma will certainly offer practical guide on exactly how to treat it, and might additionally lead to an improved understanding of just what drives others cancers as well.”

To get hold of brand-new treatments to patients as soon as possible, this five-year study will certainly include a feasibility study involving up to 30 patients, followed by Phase II clinical trials along with as numerous as 70 patients. TGen is teaming along with the Ivy Early Phase Clinical Trials Consortium that includes: University of California, San Francisco; University of California, Los Angeles; the MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; University of Utah; and the Dana-Farber/Harvard Cancer Center.

The results of these clinical trials ought to not only assistance the patients that join them, however additionally offer the data called for for FDA approval and availability of brand-new drugs that could benefit tens of thousands of brain cancer patients in the future.

“Working along with physicians, the project will certainly aim to understand treatment in the context of the tumor’s molecular profile. We will certainly have actually the opportunity to find out as quickly as combinations of drugs could be a lot more effective compared to using a single drug, rapidly identify which therapies don’t work, and accelerate discovery of ones that may prove promising for future development,” said Dr. John Carpten, TGen’s Deputy Director of Easy Science, Director of TGen’s Integrated Cancer Genomics Division, and an additional of the project’s principal investigators.

In addition to aiding patients as soon as possible, the project ought to significantly expand Arizona’s network of brain cancer experts.

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About The Ben & Catherine Ivy Foundation
The Ben & Catherine Ivy Foundation, based in Scottsdale, Ariz., was formed in 2005, as quickly as Ben Ivy lost his battle along with glioblastoma multiforme (GBM). Due to the fact that then, the Foundation has actually contributed a lot more compared to $50 million to research in gliomas within the United States and Canada, along with the objective of much better diagnostics and treatments that offer long-term survival and a higher quality of life for patients along with brain tumors. The Ben & Catherine Ivy Foundation is the largest privately funded foundation of its kind in the United States. For a lot more information, visit http://www.ivyfoundation.org. We have actually regular updates via social media – please discover us on:
Blog: Ivy Foundation http://www.IvyFoundation.wordpress.com
Facebook: Ivy Foundation http://www.facebook.com/IvyFoundation
Twitter: @IvyFoundation https://twitter.com/IvyFoundation
Google+: Ivy Foundation https://plus.google.com/115330378249248717618/posts
LinkedIn: Ivy Foundation http://linkedin.com/company/the-ben-and-catherine-ivy-foundation
YouTube: IvyFoundationGBM http://www.youtube.com/user/IvyFoundationGBM

About TGen
The Translational Genomics Research Institute (TGen) is a Phoenix-based non-profit organization dedicated to conducting groundbreaking research along with life changing results. Research at TGen is focused on aiding patients along with diseases such as cancer, neurological disorders and diabetes. TGen is on the cutting edge of translational research where investigators are able to unravel the genetic components of common and complex diseases. Working along with collaborators in the scientific and medical communities, TGen believes it can easily make a substantial supplement to the efficiency and effectiveness of the translational process. For a lot more information, visit: www.tgen.org.

South Scottsdale Market Statistics – December 2013


South Scottsdale Demographic Statistics – December 2013

Published on January 14th, 201four by ScottsdaleHomes.com

Single Family Homes Sales Trends in South Scottsdale, December 2013

Single Family members Residences Sales Fads in South Scottsdale, December 2013

December 2012 November 2013 December 2013 Monthly Adjustment in % Annual Adjustment in %
Asking Price $316,524 $354,333 $378,105 6.71% 19.46%
Sale Price $308,073 $341,301 $364,908 6.92% 18.45%
% of Asking Price 97.33% 96.32% 96.51% 0.2% -0.84%
Price/SqFt $161 $172 $191 11.05% 18.63%
DOM* 76 56 73 30.36% -3.95%
Total Transactions 83 100 93 -7% 12.05%


Condos/Townhouses Sales Trends in South Scottsdale, December 2013

Condos/Townhouses Sales Fads in South Scottsdale, December 2013

December 2012 November 2013 December 2013 Monthly Adjustment in % Annual Adjustment in %
Asking Price $229,278 $254,273 $281,751 10.81% 22.89%
Sale Price $218,543 $245,974 $260,693 5.98% 19.29%
% of Asking Price 95.32% 96.74% 92.53% -4.35% -2.93%
Price/SqFt $176 $184 $183 -0.54% 3.98%
DOM* 83 73 70 -4.11% -15.66%
Total Transactions 89 89 71 -20.22% -20.22%

Single Family members Residences Sales in South Scottsdale – December 2013
3 and four bedroom properties by zip code

85250 Asking Price $354,300
Sale Price $345,676
% of Asking Price 97.57%
Days on Market 67
Total Transactions 17
85251 Asking Price $568,272
Sale Price $544,083
% of Asking Price 95.74%
Days on Market 81
Total Transactions 27
85257 Asking Price $249,373
Sale Price $241,300
% of Asking Price 96.76%
Days on Market 64
Total Transactions 30
85258 Asking Price $444,600
Sale Price $432,333
% of Asking Price 97.24%
Days on Market 85
Total Transactions 3
85262 Asking Price $389,000
Sale Price $387,000
% of Asking Price 99.49%
Days on Market 10
Total Transactions 1

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Adoptable Dogs of the Month: Sweet Hansel & Gretel!

August’s Adoptable Dogs of the Month – Adorable Hansel & Gretel!

2nd Opportunity Pet dog Rescue‘s Dogs of the Month were rescued by Diana Czarnecki, 2nd Chance’s founder, about one year ago, and everyone is scratching their heads attempting to find out exactly how two adorable pups love Hansel & Gretel have actually not been scooped up by some lucky families (they do not necessarily should be adopted together)!

She rescued this couple from an office complex in the East Valley – they were abandoned and managed to survive for close to two weeks by leaning on each other. As small, young dogs, they would certainly never ever have actually earned it on the streets devoid of looking out for each other. Several individuals tried to rescue the couple, yet they were skittish and in “survivor mode” and didn’t trust anyone. Enter Diana Czarnecki. After spending 3 hours attempting to obtain their trust, Gretel finally gave in and Hansel wasn’t as well far behind.

When she initial rescued them, she believed for sure they would certainly should be adopted together, yet due to the fact that joining foster along with several others dogs, Hansel and Gretel have actually become independent and no longer lean on each others the method they did Once it was a matter of their survival.

Gretel is about 2 years old and is a wire-haired terrier weighing 5 pounds; she is shy at first, yet warms up rapidly and enjoys playing lap dog. Hansel is a normal boy, he loves to run and play along with the others dogs…Hansel is a Chihuahua/Dachshund mix, about 2 years old. If you are thinking about meeting the pair or simply one of them, please go to the 2nd Opportunity Pet dog Rescue website and fill out an adoption form http://2ndchance.rescuegroups.org/forms/ – somebody will certainly get hold of in to contact you after reviewing your application!

About 2nd Opportunity Pet dog Rescue:

2nd Opportunity Pet dog Rescue is a 501(c)(3) non-profit organization, located in Queen Creek, Arizona, dedicated to saving abandoned/abused dogs, and offer them along with shelter and a safe environment so they can easily regain their trust in humanity. We adopt out to loving families located within 50 miles of Queen Creek, Arizona (Tempe, Scottsdale, Gilbert, Mesa, Chandler, Phoenix). If you would certainly love to satisfy our Adoptable Pet dog of the Month, or one of others wonderful pups, please click on this link to fill out an Adoption Consultation form, or send us an email at cdczar96@aol.com and we will certainly send you the application via email).

2nd Opportunity conserves dogs that otherwise would certainly be left on the streets to fend for themselves or brought to the pound and most most likely placed on the Euthanasia List. Our dogs are very loving and deserve a spot to call home. If you are not able to provide one of our dogs a “forever” estate yet thinking about being a foster parent, or would certainly love to sponsor one of our dogs by aiding along with their medical /meals please contact us at cdczar96@aol.com.

Dogs are our link to paradise. They don’t understand evil or jealousy or discontent. To sit along with a Pet dog on a hillside on a glorious afternoon is to be spine in Eden, where executing nothing was not boring–it was peace.” ― Milan Kundera

Fountain Hills Market Statistics – December 2013


Fountain Hills Promote Statistics – December 2013

Posted on January 14th, 201four by ScottsdaleHomes.com

Single Family Homes Sales Trends in Fountain Hills, December 2013

Single Family members Residences Sales Fads in Fountain Hills, December 2013

December 2012 November 2013 December 2013 Monthly Modification in % Annual Modification in %
Asking Price $526,993 $481,392 $450,719 -6.37% -14.47%
Sale Price $507,558 $463,774 $434,562 -6.3% -14.38%
% of Asking Price 96.31% 96.34% 96.42% 0.08% 0.11%
Price/SqFt $173 $193 $180 -6.74% 4.05%
DOM* 109 109 100 -8.26% -8.26%
Total Transactions 43 25 42 68% -2.33%

Condos/Townhouses Sales Trends in Fountain Hills, December 2013

Condos/Townhouses Sales Fads in Fountain Hills, December 2013

December 2012 November 2013 December 2013 Monthly Modification in % Annual Modification in %
Asking Price $168,082 $185,089 $169,753 -8.29% 0.99%
Sale Price $156,364 $180,321 $162,413 -9.93% 3.87%
% of Asking Price 93.03% 97.42% 95.68% -1.79% 2.85%
Price/SqFt $122 $150 $132 -12% 8.2%
DOM* 51 101 108 6.93% 111.76%
Total Transactions 11 14 15 7.14% 36.36%

Single Family members Residences Sales in Fountain Hills by Lot of Bedrooms and by Zip Code

Bedrooms Zip Code Average Asking Price Avergage Sale Price % of Asking Price Sold Average DOM Average SqFt Average Fee each SqFt
2 85268 $325,160 $312,000 95.95% 5 98 1,632 $191
3 85268 $446,373 $430,014 96.34% 22 117 2,271 $189
4 85268 $526,492 $507,615 96.41% 13 78 2,947 $172
5 85268 $389,900 $369,000 94.64% 1 99 2,237 $165
6 85268 $249,900 $263,300 105.36% 1 23 3,010 $87

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Scottsdale

 

Are you tired of dealing along with light wrinkles, great lines, and uneven skin tone? Scottsdale Fraxel laser resurfacing is a great option for addressing these troubles since it alters the appearance of aging and sun-damaged skin over time. Essentially, Scottsdale Fraxel stimulated the body’s own restorative procedures through controlled treatments performed on the skin. The laser activity of this treatment encourages the production of brand-new collagen, giving the skin a healthier, a lot more vibrant appearance while filling in great lines and wrinkles.

 

How does it Work?

 

Fraxel employs the most up to date in skin care laser technology to stimulate the body’s collagen production. Rather than harsh chemical peels, which Job by removing layers of skin from targeted areas, Scottsdale Fraxel does not remove any kind of skin. Instead, it targets the complications below the surface of the epidermis, lowering recovery time and encouraging the skin to make collagen and fix points enjoy wrinkles on its own. So, outcomes are seen faster compared to along with various other treatments since there are no chemicals or harsh treatments applied to the skin; instead, your skin is the one doing all of the work, so your outcomes are permanently natural. It is primarily used for aesthetic troubles to combat early signs of aging, including light wrinkles and sunspots.

 

If you suffer from deeper facial lines and folds, your technician may recommend that you think about looking in to a lot more intensive procedures. For instance, deep wrinkles will certainly incentive a lot more from face and brow lifts Rather than laser resurfacing. However, you need to talk to your technician to ensure that you’re looking in to the right procedure.

 

Is Fraxel Right for Me?

 

Fraxel is not the right solution for everyone, yet if you suffer from age spots, sun damage, acne scars, or superficial wrinkles near the eyes, you can easily stand to incentive from this procedure. Skin disorders that create unwanted pigmentation can easily likewise incentive from the skin resurfacing offered by Scottsdale Fraxel. This treatment will certainly permit you to return to your day-to-day tasks relatively quickly, though recovery times vary largely depending on the extent of the skin you’re having treated and your specific skin needs. outcomes appear regarding two to three months after treatment. This form of laser resurfacing is a excellent option for individuals that are curious about benefitting from the physique healing itself, as opposed to chemical or mechanical stripping. Scottsdale Fraxel safely and effectively encourages the development of brand-new collagen, yet you need to make certain that you are functioning along with a qualified professional so that you can easily receive optimum incentives from this treatment.